The daughter of Peter Parker and Mary Jane Watson, Sera lived a relatively peaceful life with her Family. However, once the symbiote invasion began, SHIELD took Sera from her family and held her in the Helicarrier to ensure Spider Man's cooperation. When Spider-Man refused to cooperate due to his family being threatened, Silver Sable and Black Widow held Sera at gunpoint. At this moment, Sera's powers emerged for the first time, and she impaled Silver Sable with a spear of webbing. However, following this, Sera was shot by Black Widow. On the Astral plane, Sera met Madame Web, who offered her life back in exchange for serving as the new Arachne. Sera agreed, and was revived, and Black Widow was promptly arrested.